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A highly regarded scientist in biomedical research, Dr. Goldberger became NIH deputy director for science in September 1979.

After receiving his A.B. degree from Harvard College in 1954, he attended the New York University Medical School, where he obtained an M.D. in 1958. He interned at Mt. Sinai Hospital in New York, and then spent 2 years as a post- doctoral fellow at the University of Wisconsin's Institute for Enzyme Research. He came to the NIH as a research associate in the National Heart Institute in 1961, working with Dr. C. B. Anfinsen on the mechanism by which newly synthesized polypeptide chains attain three-dimensional structures characteristic of native proteins. In 1963 he was a visiting scientist at the Weizmann Institute of Science.

Dr. Goldberger served as a biochemist in the Laboratory of Chemical Biology, NIAMD, from 1963 to 1966, when he became chief of that laboratory's Biosynthesis and Control Section. He worked on regulation of gene expression in bacteria.

In 1973 he moved to the NCI's Division of Cancer Biology and Diagnosis, where, as chief of the cellular regulation section, he worked on hormonal regulation of gene expression in avian liver.

Dr. Goldberger has written one book on biochemistry and has edited a multivolume treatise on biological regulation. From 1970 to 1971 he served as president of NIH's Inter-Assembly Council of the Assemblies of Scientists. He received the Superior Service Award, DHEW, in 1973 and the Meritorious Service Medal, USPHS, in 1977.

At the end of June 1981, he left NIH to accept a dual position as provost of Columbia University and vice president for health sciences, and as a professor of chemistry.